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Advanced level research in collaboration with a faculty member, which may involve projects in one or more of the following areas: organic synthesis, isolation and structure elucidation, metabolism, biochemical mechanisms of drug action. Prerequisite: Doctoral degree or equivalent in an appropriate related area, and consent of instructor. RSH
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Hours and credit to be arranged. Original chemical research in the synthesis and development of medicinal agents, elucidation of the chemical mechanisms of drug action, drug metabolism, and drug toxicities. THE
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The course will build an in depth knowledge about basic mechanisms of synaptic communication among nerve cells and their targets, and the structure and function of nervous systems. Topics will include nervous system development and synapse formation, structure and function of neurons, physiological and molecular basis of synaptic communication between neurons, mechanisms of synaptic plasticity involved in learning and memory, sensory systems (vision, auditory, vestibular, motor reflexes and pain), processing of neural information at cellular and system levels, synapse regeneration and diseases of the nervous system. Prerequisite: BIOL 435 (Introduction to Neurobiology), or consent of instructor. LEC
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A detailed study of the molecular aspects of nerve transmission will be covered with special emphasis on the uptake, storage, release, biosynthesis, and metabolism of specific neurotransmitters. Drugs affecting these processes and current research on receptor isolation and receptor mechanisms will be discussed from a chemical viewpoint. (Same as BIOL 775, CHEM 775, MDCM 775, P&TX 775, and PHCH 775.) Prerequisite: BIOL 600 or equivalent. LEC
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Presentations of research papers by faculty, post-doctoral research associates, and graduate students. All graduate students in the Neuroscience program participate in this seminar series throughout their period of training. Each student has to present a seminar once every semester. Presentations by students are evaluated by other graduate students and faculty at the end of each seminar. Prerequisite: Graduate standing in the Neuroscience program. LEC
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This course is to be used by graduate students fulfilling the teaching requirements for the Ph.D. in Neuroscience. The student will function as a discussion leader and lecturer in a limited number of class sessions. Each student will meet with faculty whom he or she is assisting in preparation of presentation materials and tests. Each student will be evaluated by the faculty mentor and by the students in the class taught. Prerequisite: Graduate standing in Neuroscience. LEC
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Lectures and discussion on ethical issues in the conduct of a scientific career, with emphasis on practical topics of special importance in molecular-level research in the chemical, biological, and pharmaceutical sciences. Topics will include the nature of ethics, the scientist in the laboratory, the scientist as author, grantee, reviewer, employer/employee, teacher, student, and citizen. Discussions will focus on case histories. Graded on a satisfactory/unsatisfactory basis. (Same as MDCM 801, P&TX 801, PHCH 801 and PHCH 802.) Prerequisite: Graduate standing in the Neuroscience program. LEC
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The course will cover basic techniques of moral reasoning, especially as applied to ethical issues in the physical sciences and engineering. Topics covered will include the ethical conduct of research, the federal and professional guidelines for different kinds of research, and the ethical dimensions of publication and professional life. Emphasis will be on practical applications, cases and student involvement. (Same as GS 804, MDCM 804, P&TX 804, and PHCH 804.) Prerequisite: Must be admitted to the program or division of Pharmacy to enroll in this class. LEC
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Original investigations at an advanced level in the areas of neuroscience. The research by each student will be performed in the laboratory of one of the faculty mentors of the graduate program in Neuroscience. Prerequisite: Graduate standing in the Neuroscience program. LEC
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Somatosensory, motor and cognitive function of the brain will be discussed using a combination of lecture and student presentation formats. Current issues and evidence underlying accepted concepts and mechanisms will be emphasized. (Same as PHSL 844.) Prerequisite: PHSL 846 or equivalent and consent of instructor. LEC
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Team-taught, in-depth neuroscience course focusing on normal and diseased brain function at the molecular, cellular and systems levels. Lectures and discussions will emphasize current issues in neuroscience research. (Same as ANAT 846, PHCL 846, and PHSL 846.) Prerequisite: Permission of the course instructor. LEC
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Development of the nervous system from early induction to the development of learning and memory. Topics include: Induction; Cellular Differentiation; Axon Growth and Guidance; Target Selection; Cell Survival and Growth; Synapse Formation; Synapse Elimination; and Development of Behavior. (Same as ANAT 847 and PHSL 847.) Prerequisite: Advanced Neuroscience (ANAT 846; NURO 846; PHSL 846) or consent of instructor. LEC
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An in-depth coverage of pathogenic mechanisms in neurological diseases; cellular and molecular responses to brain injury and disease, neuroinflammatory diseases (e.g., multiple sclerosis), neurodegenerative diseases (e.g., Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases), neurogenetic diseases (e.g., lysosomal and peroxisomal disorders, Down's syndrome and fragile X), trauma, stroke, and viral diseases (e.g., HIV encephalitis). (Same as ANAT 848, PHCL 848, and PHSL 848.) Prerequisite: Advanced Neuroscience (ANAT 846, PHCL 846 or PHSL 846) or an equivalent course and consent of instructor. LEC
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Hours and credit for this course to be arranged with the mentor. Independent investigation of a research problem in neuroscience, but of limited scope. Prerequisite: Graduate standing in the Neuroscience program and consent of mentor/instructor. THE
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Hours and credit for this course to be arranged with the mentor. Conduct of original investigation in neurosciences. Prerequisite: Graduate standing in the Neuroscience program post-oral comprehensive examination and consent of mentor/instructor. THE
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The pharmacology series covers the mechanisms by which drugs interact with living organisms. An integrative emphasis will be placed on understanding the molecular basis of drug action with respect to modifying the pathophysiology of specific disease states. Topics in P&TX 630 include, general principles of cell biology, molecular biology, pharmacogenomics, immunology and principles of drug metabolism and disposition. Prerequisite: BIOL 646 or equivalent. LEC
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The pharmacology series covers the mechanisms by which drugs interact with living organisms. An integrative emphasis will be placed on understanding the molecular basis of drug action with respect to modifying the pathophysiology of specific disease states. Topics in P&TX 631 include, hematology, cancer biology and therapeutics, immunopharmacology, infectious diseases and respiratory disease. Prerequisite: P&TX 630 and BIOL 400 or equivalent. LEC
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The pharmacology series covers the mechanisms by which drugs interact with living organisms. An integrative emphasis will be placed on understanding the molecular basis of drug action with respect to modifying the pathophysiology of specific disease states. Topics in P&TX 632 include, cardiovascular diseases, diuretics, autonomic pharmacology and drugs regulating central nervous system function. Prerequisite: P&TX 630 and P&TX 631. LEC
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The pharmacology series covers the mechanisms by which drugs interact with living organisms. An integrative emphasis will be placed on understanding the molecular basis of drug action with respect to modifying the pathophysiology of specific disease states. Topics in P&TX 633 include endocrine disorders, diabetes and obesity, and gastrointestinal pharmacology. Prerequisite: P&TX 630, P&TX 631 and P&TX 632. LEC
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General principles of toxicology, treatment, and management of accidental poisoning, and current topics of interest. Prerequisite: P&TX 630, P&TX 631, and P&TX 632. LEC
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Students will read about and discuss the latest research on new antibiotic targets, therapeutic potential, disease prevention, and the emergence of antibiotic resistance. LEC
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The objective of this course is to provide students with an opportunity to read, examine, and report on a broad array of topics relevant to diabetes and obesity. Students will be given broad latitude to propose topics of interest to them within the area of diabetes and obesity. The format of the course will be group presentations. Groups of 3 students will identify a topic of interest to them in the field of diabetes and obesity, prepare a 30 min presentation and deliver it to the class for discussion. Prerequisite: P&TX 630. LEC
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Neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, are associated with older age and/or enhanced oxidative stress. The possible causes for the development and progression of these diseases with relation to current research in the field will be discussed. Additionally, a summary of available and suggested future treatments will be given. Prerequisite: P&TX 630. LEC
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Several addictions will be discussed including addictions to alcohol, cocaine, methamphetamine, gambling, and others as time permits. The physiology, biochemistry, pharmacology and available treatments for these addictions will be reviewed. The role of pharmacotherapies will be discussed, particularly as they relate to the molecular basis of addiction. Behavioral and psychological approaches also will be examined. Prerequisite: Completion of P&TX 632 or special permission from faculty. LEC
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Original research on a laboratory problem of limited scope. This course cannot count toward pharmacology and toxicology requirements in the School of Pharmacy. Prerequisite: Consent of instructor. IND
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Original library review of a limited special topic in pharmacology and toxicology. The student will write a review in his or her report. This course may count toward pharmacology and toxicology requirements in the School of Pharmacy. Prerequisite: P&TX 635 and consent of instructor. IND
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A course designed to assist doctoral students in the biomedical sciences in their professional development by providing presentations, discussions, and practical experiences related to career planning. Topics include diverse career opportunities and expectations of each, preparation of vitae/resumes and other elements of a successful job search, writing scientific papers and dealing with editors, developing programmatic research programs, balancing professional obligations, advancing through promotions, and related topics. Prerequisite: Graduate standing in pharmacology and toxicology. LEC
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This course will examine the bases for reciprocal dynamic interactions between central nervous system function and structure ("nature") and experience ("nurture"). "Nature" will be explored using principles and methodologies derived from systems and molecular pharmacology, and neurochemistry. The effects of "nurture" on brain will involve issues derived from behavioral pharmacology, environmental enrichment, and human brain imaging. During the course, with the help of the instructor, students will be expected to discuss and critically analyze research articles for subsequent presentation to the class. LEC
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The use of the library as a research tool and the study of bibliographic techniques of literature searching. Emphasis on pharmacological, physiological, biochemical, and medical literature. Graded on a satisfactory/unsatisfactory basis. Prerequisite: Graduate standing. LEC
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A detailed study of the fundamentals of autonomic nervous system, central nervous system, and their pharmacology. The student will attend P&TX 632 lectures and meet separately with the faculty for additional discussions of advanced material on the topics. The students will be examined on the advanced material. Prerequisite: Graduate standing in pharmacology and toxicology. LEC
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